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Year : 2017  |  Volume : 4  |  Issue : 3  |  Page : 87-90

Probable lamivudine-resistant hepatitis B infection in children: A case report involving two Nigerian siblings at Ahmadu Bello University Teaching Hospital, Shika, Zaria

Department of Paediatrics, ABU/ABUTH-Zaria, Zaria, Nigeria

Correspondence Address:
Sani M Mado
Department of Paediatrics, ABU/ABUTH-Zaria, Zaria
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ssajm.ssajm_21_17

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Currently, up to 65 million Africans have chronic hepatitis B (CHB) infection, with the majority acquiring it in the first 5 years of life and living in Nigeria. Lamivudine is generally accepted for use as the first-line treatment of CHB in children under the age of 12 years. However, the drug has a low genetic barrier to resistance. Lamivudine-resistant CHB is a serious challenge in resource-limited settings. This case report is intended to study a probable lamivudine-resistant CHB in two siblings aged 9 and 11 years and to highlight the challenges of managing CHB in children from resource-limited settings. There is a need to develop national guidelines for the management of CHB in children. Other suitable antiviral agents should be subsidized, so that they could be used to salvage lamivudine-resistant cases.

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